Drug interactions
Diazepam intranasal + Pregabalin
Severity: Major
Diazepam intranasal and Pregabalin: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazepam and pregabalin both depress the CNS, so combined use increases sedation, impaired coordination and the risk of respiratory depression. The risk is greater in the elderly and those with respiratory disease.
What this interaction means in plain words
Diazepam intranasal and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression through GABAergic benzodiazepine effects plus pregabalin.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression. Avoid other sedatives and alcohol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Alzain 100 mg Capsules, Hard - SmPC sections 4.3/4.5 (class statement: other central nervous system (CNS) depressant medicinal products; "there are reports of respiratory failure, coma and deaths in patients taking pregabalin and opioids and/or other central nervous system (CNS) depressant medicin") — electronic medicines compendium (UK SmPC)
Other interactions of Pregabalin
Frequently asked questions
Can I take Diazepam intranasal with Pregabalin?
MediHelp rates the interaction as major. Diazepam intranasal and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diazepam and pregabalin both depress the CNS, so combined use increases sedation, impaired coordination and the risk of respiratory depression. The risk is greater in the elderly and those with respiratory disease.
How serious is the interaction between Diazepam intranasal and Pregabalin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression. Avoid other sedatives and alcohol.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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