Drug interactions
Diazepam intranasal + Trazodone
Severity: Moderate
Diazepam intranasal and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines and trazodone both depress the central nervous system. Their combination can produce deeper sedation, impaired coordination and, at higher doses, respiratory depression.
What this interaction means in plain words
Diazepam intranasal and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and trazodone's sedative effects.
What to do
Use the lowest effective doses and monitor for excessive sedation and respiratory depression. Counsel patients to avoid alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Trazodone?
MediHelp rates the interaction as moderate. Diazepam intranasal and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzodiazepines and trazodone both depress the central nervous system. Their combination can produce deeper sedation, impaired coordination and, at higher doses, respiratory depression.
How serious is the interaction between Diazepam intranasal and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for excessive sedation and respiratory depression. Counsel patients to avoid alcohol and driving.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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