Drug interactions
Diazepam intranasal + Vortioxetine
Severity: Moderate
Diazepam intranasal and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazepam is a benzodiazepine that causes sedation and psychomotor impairment, and vortioxetine can occasionally cause drowsiness and dizziness. Combined use may increase CNS depression, though the effect is usually modest.
What this interaction means in plain words
Diazepam intranasal and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Advise patients to avoid driving or hazardous tasks after a dose. Monitor for excessive sedation, particularly in older or frail patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Vortioxetine?
MediHelp rates the interaction as moderate. Diazepam intranasal and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diazepam is a benzodiazepine that causes sedation and psychomotor impairment, and vortioxetine can occasionally cause drowsiness and dizziness. Combined use may increase CNS depression, though the effect is usually modest.
How serious is the interaction between Diazepam intranasal and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving or hazardous tasks after a dose. Monitor for excessive sedation, particularly in older or frail patients.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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