Drug interactions
Diazoxide + Enalapril-hydrochlorothiazide
Severity: Moderate
Diazoxide and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides and diazoxide both raise blood glucose, and thiazides can potentiate diazoxide's hyperglycemic and hypotensive effects. This may undermine glucose control, especially when diazoxide is used for hyperinsulinism, and can lower blood pressure further with enalapril.
What this interaction means in plain words
Diazoxide and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazoxide belongs to Miscellaneous; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive hyperglycemic effects via reduced insulin secretion, plus additive vasodilatory and hypotensive effects.
What to do
Monitor blood glucose and blood pressure, particularly at initiation or dose changes. Adjust diazoxide or antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Diazoxide
Frequently asked questions
Can I take Diazoxide with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Diazoxide and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides and diazoxide both raise blood glucose, and thiazides can potentiate diazoxide's hyperglycemic and hypotensive effects. This may undermine glucose control, especially when diazoxide is used for hyperinsulinism, and can lower blood pressure further with enalapril.
How serious is the interaction between Diazoxide and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and blood pressure, particularly at initiation or dose changes. Adjust diazoxide or antidiabetic therapy as needed.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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