Drug interactions
Diazoxide + Fosinopril-hydrochlorothiazide
Severity: Moderate
Diazoxide and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both thiazides and diazoxide can raise blood glucose, and diazoxide is chemically related to thiazides. Combined use can cause marked hyperglycemia, and additive hypotension, hyperuricemia and electrolyte disturbance may occur.
What this interaction means in plain words
Diazoxide and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazoxide belongs to Miscellaneous; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive suppression of insulin secretion and hyperglycemic effects, with additive hypotensive and fluid effects.
What to do
Monitor blood glucose, electrolytes and blood pressure, and adjust diazoxide dose or antidiabetic therapy accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Diazoxide
Frequently asked questions
Can I take Diazoxide with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Diazoxide and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both thiazides and diazoxide can raise blood glucose, and diazoxide is chemically related to thiazides. Combined use can cause marked hyperglycemia, and additive hypotension, hyperuricemia and electrolyte disturbance may occur.
How serious is the interaction between Diazoxide and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, electrolytes and blood pressure, and adjust diazoxide dose or antidiabetic therapy accordingly.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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