Drug interactions
Diazoxide + Hydrochlorothiazide-losartan
Severity: Moderate
Diazoxide and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both thiazides and diazoxide cause hyperglycemia and can also lower blood pressure, so combining them may increase hyperglycemia and hypotension. This matters most in patients using diazoxide to treat hypoglycemia.
What this interaction means in plain words
Diazoxide and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazoxide belongs to Miscellaneous; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Additive suppression of insulin release and impaired glucose tolerance, with additive vasodilatory and hypotensive effects.
What to do
Monitor blood glucose and blood pressure, and adjust the diazoxide dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Diazoxide
Frequently asked questions
Can I take Diazoxide with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Diazoxide and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both thiazides and diazoxide cause hyperglycemia and can also lower blood pressure, so combining them may increase hyperglycemia and hypotension. This matters most in patients using diazoxide to treat hypoglycemia.
How serious is the interaction between Diazoxide and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and blood pressure, and adjust the diazoxide dose as needed.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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