Drug interactions
Dichlorphenamide + Digoxin
Severity: Moderate
Dichlorphenamide and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide, a carbonic anhydrase inhibitor, increases urinary potassium loss and can cause hypokalemia. Low potassium sensitizes the myocardium to digoxin and raises the risk of arrhythmias.
What this interaction means in plain words
Dichlorphenamide and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Digoxin belongs to Cardiovascular.
Why it happens
Carbonic anhydrase inhibition causes renal potassium wasting, and hypokalemia enhances digoxin cardiac toxicity.
What to do
Monitor serum potassium and correct hypokalemia, and check digoxin levels and ECG if potassium falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Digoxin?
MediHelp rates the interaction as moderate. Dichlorphenamide and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide, a carbonic anhydrase inhibitor, increases urinary potassium loss and can cause hypokalemia. Low potassium sensitizes the myocardium to digoxin and raises the risk of arrhythmias.
How serious is the interaction between Dichlorphenamide and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and correct hypokalemia, and check digoxin levels and ECG if potassium falls.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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