Drug interactions
Dichlorphenamide + Duloxetine
Severity: Minor
Dichlorphenamide and Duloxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide causes renal potassium wasting and can lower serum potassium. Duloxetine is rarely associated with hyponatremia and only weakly with potassium changes, so the additive effect is modest and mostly theoretical.
What this interaction means in plain words
Dichlorphenamide and Duloxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dichlorphenamide belongs to Miscellaneous; Duloxetine belongs to Central Nervous System.
Why it happens
Carbonic anhydrase inhibition by dichlorphenamide increases urinary potassium loss; duloxetine contributes little, so the additive effect is not well established.
What to do
Check serum potassium and sodium periodically, particularly in patients with other risk factors for electrolyte disturbance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Duloxetine?
MediHelp rates the interaction as minor. Dichlorphenamide and Duloxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dichlorphenamide causes renal potassium wasting and can lower serum potassium. Duloxetine is rarely associated with hyponatremia and only weakly with potassium changes, so the additive effect is modest and mostly theoretical.
How serious is the interaction between Dichlorphenamide and Duloxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and sodium periodically, particularly in patients with other risk factors for electrolyte disturbance.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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