Drug interactions
Dichlorphenamide + Esomeprazole
Severity: Moderate
Dichlorphenamide and Esomeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum potassium, and the effects may add together. Hypokalemia can cause weakness and arrhythmia, and it is particularly relevant in periodic paralysis.
What this interaction means in plain words
Dichlorphenamide and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Esomeprazole belongs to Gastrointestinal Tract.
Why it happens
Additive potassium loss: dichlorphenamide causes renal potassium wasting while PPIs can contribute to hypokalemia and hypomagnesemia.
What to do
Check serum potassium and magnesium at baseline and periodically, and correct deficits promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Esomeprazole?
MediHelp rates the interaction as moderate. Dichlorphenamide and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum potassium, and the effects may add together. Hypokalemia can cause weakness and arrhythmia, and it is particularly relevant in periodic paralysis.
How serious is the interaction between Dichlorphenamide and Esomeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium at baseline and periodically, and correct deficits promptly.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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