Drug interactions
Dichlorphenamide + Fluconazole
Severity: Moderate
Dichlorphenamide and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide causes potassium loss and metabolic acidosis, and fluconazole may be associated with hypokalemia and QT prolongation. Combined use may worsen hypokalemia and its arrhythmic consequences.
What this interaction means in plain words
Dichlorphenamide and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Fluconazole belongs to Anti Fungals.
Why it happens
Additive potassium-lowering effects; fluconazole's hypokalemic effect is not well characterized.
What to do
Monitor serum potassium and bicarbonate regularly and replace potassium as needed. Consider ECG monitoring if hypokalemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Fluconazole?
MediHelp rates the interaction as moderate. Dichlorphenamide and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide causes potassium loss and metabolic acidosis, and fluconazole may be associated with hypokalemia and QT prolongation. Combined use may worsen hypokalemia and its arrhythmic consequences.
How serious is the interaction between Dichlorphenamide and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate regularly and replace potassium as needed. Consider ECG monitoring if hypokalemia occurs.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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