Drug interactions
Dichlorphenamide + Hydrochlorothiazide
Severity: Moderate
Dichlorphenamide and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs increase renal potassium excretion, so combined use raises the risk of significant hypokalaemia. Dichlorphenamide also causes metabolic acidosis, which may complicate electrolyte disturbances.
What this interaction means in plain words
Dichlorphenamide and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive kaliuresis from carbonic anhydrase inhibition and thiazide diuresis.
What to do
Monitor potassium and bicarbonate regularly and replace potassium as needed. Reassess the need for the diuretic if levels are difficult to maintain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Dichlorphenamide and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs increase renal potassium excretion, so combined use raises the risk of significant hypokalaemia. Dichlorphenamide also causes metabolic acidosis, which may complicate electrolyte disturbances.
How serious is the interaction between Dichlorphenamide and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and bicarbonate regularly and replace potassium as needed. Reassess the need for the diuretic if levels are difficult to maintain.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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