Drug interactions
Dichlorphenamide + Insulin degludec-insulin aspart
Severity: Moderate
Dichlorphenamide and Insulin degludec-insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can lower serum potassium, and together the risk of clinically significant hypokalemia increases. Hypokalemia may cause weakness and arrhythmias.
What this interaction means in plain words
Dichlorphenamide and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Insulin degludec-insulin aspart belongs to Endocrine.
Why it happens
Insulin shifts potassium into cells while dichlorphenamide increases renal potassium loss through carbonic anhydrase inhibition.
What to do
Monitor serum potassium regularly and replace potassium as required, especially when insulin doses are high or changed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Insulin degludec-insulin aspart?
MediHelp rates the interaction as moderate. Dichlorphenamide and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can lower serum potassium, and together the risk of clinically significant hypokalemia increases. Hypokalemia may cause weakness and arrhythmias.
How serious is the interaction between Dichlorphenamide and Insulin degludec-insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium regularly and replace potassium as required, especially when insulin doses are high or changed.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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