Drug interactions
Dichlorphenamide + Lenvatinib
Severity: Moderate
Dichlorphenamide and Lenvatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide lowers potassium and may cause acidosis. Lenvatinib can cause diarrhea, electrolyte disturbances, and QT prolongation, so combined use may increase the consequences of hypokalemia.
What this interaction means in plain words
Dichlorphenamide and Lenvatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Lenvatinib belongs to Oncology.
Why it happens
Additive electrolyte disturbance with potential QT risk; dichlorphenamide-induced kaliuresis adds to lenvatinib-associated losses.
What to do
Monitor serum potassium, magnesium, and bicarbonate regularly, and correct deficits promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dichlorphenamide
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Dichlorphenamide with Lenvatinib?
MediHelp rates the interaction as moderate. Dichlorphenamide and Lenvatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide lowers potassium and may cause acidosis. Lenvatinib can cause diarrhea, electrolyte disturbances, and QT prolongation, so combined use may increase the consequences of hypokalemia.
How serious is the interaction between Dichlorphenamide and Lenvatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, magnesium, and bicarbonate regularly, and correct deficits promptly.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
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