Drug interactions
Dichlorphenamide + Metolazone
Severity: Moderate
Dichlorphenamide and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents increase urinary potassium loss, and together they can cause significant hypokalemia and metabolic disturbances. Dichlorphenamide also causes metabolic acidosis, which adds to the electrolyte burden.
What this interaction means in plain words
Dichlorphenamide and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Metolazone belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting from carbonic anhydrase inhibition and thiazide-like diuresis.
What to do
Monitor serum potassium and bicarbonate at baseline and periodically, and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Metolazone?
MediHelp rates the interaction as moderate. Dichlorphenamide and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents increase urinary potassium loss, and together they can cause significant hypokalemia and metabolic disturbances. Dichlorphenamide also causes metabolic acidosis, which adds to the electrolyte burden.
How serious is the interaction between Dichlorphenamide and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate at baseline and periodically, and replace potassium as needed.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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