Drug interactions
Dichlorphenamide + Ondansetron
Severity: Moderate
Dichlorphenamide and Ondansetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide causes potassium loss and metabolic acidosis, and hypokalemia increases susceptibility to QT prolongation and torsades de pointes with ondansetron. The risk is mainly indirect and rises in patients with other risk factors.
What this interaction means in plain words
Dichlorphenamide and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Carbonic anhydrase inhibition causes renal potassium wasting; resulting hypokalemia adds to ondansetron-related QT prolongation.
What to do
Monitor serum potassium and replace as needed; obtain an ECG if other QT-prolonging factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Ondansetron?
MediHelp rates the interaction as moderate. Dichlorphenamide and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide causes potassium loss and metabolic acidosis, and hypokalemia increases susceptibility to QT prolongation and torsades de pointes with ondansetron. The risk is mainly indirect and rises in patients with other risk factors.
How serious is the interaction between Dichlorphenamide and Ondansetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and replace as needed; obtain an ECG if other QT-prolonging factors are present.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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