Drug interactions
Dichlorphenamide + Panobinostat
Severity: Major
Dichlorphenamide and Panobinostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat causes QT prolongation and frequently causes diarrhea and electrolyte abnormalities including hypokalemia. Dichlorphenamide further lowers potassium, increasing the risk of serious arrhythmias.
What this interaction means in plain words
Dichlorphenamide and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dichlorphenamide belongs to Miscellaneous; Panobinostat belongs to Oncology.
Why it happens
Dichlorphenamide-induced hypokalemia and acidosis add to panobinostat's QT-prolonging and electrolyte-depleting effects.
What to do
Check potassium and magnesium before starting and regularly during treatment, correct abnormalities, and monitor ECG as recommended for panobinostat.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dichlorphenamide
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Dichlorphenamide with Panobinostat?
MediHelp rates the interaction as major. Dichlorphenamide and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Panobinostat causes QT prolongation and frequently causes diarrhea and electrolyte abnormalities including hypokalemia. Dichlorphenamide further lowers potassium, increasing the risk of serious arrhythmias.
How serious is the interaction between Dichlorphenamide and Panobinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium before starting and regularly during treatment, correct abnormalities, and monitor ECG as recommended for panobinostat.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
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