Drug interactions
Dichlorphenamide + Temsirolimus
Severity: Moderate
Dichlorphenamide and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide, a carbonic anhydrase inhibitor, causes hypokalemia and metabolic acidosis. Temsirolimus can cause electrolyte disturbances including hypokalemia, so the combination may worsen these abnormalities.
What this interaction means in plain words
Dichlorphenamide and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Temsirolimus belongs to Oncology.
Why it happens
Additive pharmacodynamic effects on potassium loss and acid-base balance.
What to do
Monitor serum potassium and bicarbonate at baseline and periodically during combined use. Replace potassium and adjust therapy if acidosis or hypokalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Temsirolimus?
MediHelp rates the interaction as moderate. Dichlorphenamide and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide, a carbonic anhydrase inhibitor, causes hypokalemia and metabolic acidosis. Temsirolimus can cause electrolyte disturbances including hypokalemia, so the combination may worsen these abnormalities.
How serious is the interaction between Dichlorphenamide and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate at baseline and periodically during combined use. Replace potassium and adjust therapy if acidosis or hypokalemia develops.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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