Drug interactions
Diclofenac + Diflunisal
Severity: Moderate
Diclofenac and Diflunisal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two NSAIDs together raise gastrointestinal, renal and cardiovascular risk without added benefit. Bleeding, kidney injury and hyperkalemia become more likely.
What this interaction means in plain words
Diclofenac and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Diflunisal belongs to Musculoskeletal.
Why it happens
Additive cyclooxygenase inhibition affecting platelets, gastric mucosa and renal prostaglandins.
What to do
Avoid duplicate NSAID therapy and use a single agent at the lowest effective dose. If both have been taken, monitor renal function, potassium and for GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Diflunisal?
MediHelp rates the interaction as moderate. Diclofenac and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two NSAIDs together raise gastrointestinal, renal and cardiovascular risk without added benefit. Bleeding, kidney injury and hyperkalemia become more likely.
How serious is the interaction between Diclofenac and Diflunisal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate NSAID therapy and use a single agent at the lowest effective dose. If both have been taken, monitor renal function, potassium and for GI bleeding.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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