Drug interactions
Diclofenac + Eltrombopag
Severity: Minor
Diclofenac and Eltrombopag: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits UGT enzymes and OATP1B1 in vitro, so it could raise exposure to diclofenac, which undergoes glucuronidation. The clinical significance is unclear.
What this interaction means in plain words
Diclofenac and Eltrombopag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diclofenac belongs to Musculoskeletal; Eltrombopag belongs to Miscellaneous.
Why it happens
Possible inhibition of UGT-mediated diclofenac glucuronidation by eltrombopag.
What to do
No dose adjustment is usually required. Monitor for diclofenac adverse effects, and note that NSAIDs also add bleeding risk in thrombocytopenic patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Diclofenac with Eltrombopag?
MediHelp rates the interaction as minor. Diclofenac and Eltrombopag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits UGT enzymes and OATP1B1 in vitro, so it could raise exposure to diclofenac, which undergoes glucuronidation. The clinical significance is unclear.
How serious is the interaction between Diclofenac and Eltrombopag?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required. Monitor for diclofenac adverse effects, and note that NSAIDs also add bleeding risk in thrombocytopenic patients.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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