Drug interactions
Diclofenac + Emtricitabine
Severity: Moderate
Diclofenac and Emtricitabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Emtricitabine is eliminated by glomerular filtration and active tubular secretion, and NSAIDs can reduce renal function. This may raise emtricitabine concentrations and the risk of renal adverse effects, especially with high-dose or prolonged NSAID use.
What this interaction means in plain words
Diclofenac and Emtricitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Emtricitabine belongs to Anti Virals.
Why it happens
NSAID-induced reduction in renal perfusion and possible competition for tubular secretion reduces emtricitabine clearance.
What to do
Prefer a non-NSAID analgesic; if an NSAID is needed, use the lowest dose briefly and monitor serum creatinine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Emtricitabine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Emtricitabine Contraindicated
- Atidarsagene autotemcel + Emtricitabine Major
- Betibeglogene autotemcel + Emtricitabine Major
- Elivaldogene autotemcel + Emtricitabine Major
- Emtricitabine + Lamivudine Major
- Emtricitabine + Lovotibeglogene autotemcel Major
Frequently asked questions
Can I take Diclofenac with Emtricitabine?
MediHelp rates the interaction as moderate. Diclofenac and Emtricitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Emtricitabine is eliminated by glomerular filtration and active tubular secretion, and NSAIDs can reduce renal function. This may raise emtricitabine concentrations and the risk of renal adverse effects, especially with high-dose or prolonged NSAID use.
How serious is the interaction between Diclofenac and Emtricitabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic; if an NSAID is needed, use the lowest dose briefly and monitor serum creatinine.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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