Drug interactions
Diclofenac + Fluoxetine
Severity: Moderate
Diclofenac and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine impairs platelet serotonin uptake and, with diclofenac, raises the risk of upper gastrointestinal bleeding. Fluoxetine also inhibits CYP2C9, which may modestly increase diclofenac exposure.
What this interaction means in plain words
Diclofenac and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Fluoxetine belongs to Central Nervous System.
Why it happens
Additive effects on platelet function and gastric mucosa, plus CYP2C9 inhibition by fluoxetine.
What to do
Consider a proton pump inhibitor for gastroprotection and use the lowest effective diclofenac dose. Counsel patients to report melena or hematemesis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Diclofenac with Fluoxetine?
MediHelp rates the interaction as moderate. Diclofenac and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine impairs platelet serotonin uptake and, with diclofenac, raises the risk of upper gastrointestinal bleeding. Fluoxetine also inhibits CYP2C9, which may modestly increase diclofenac exposure.
How serious is the interaction between Diclofenac and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a proton pump inhibitor for gastroprotection and use the lowest effective diclofenac dose. Counsel patients to report melena or hematemesis.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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