Drug interactions
Diclofenac + Mifepristone
Severity: Moderate
Diclofenac and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP2C9 and CYP2C8, which may increase systemic exposure to diclofenac. With topical diclofenac systemic exposure is low, so the effect is usually small, but oral use carries greater risk.
What this interaction means in plain words
Diclofenac and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibition of CYP2C9 (and CYP2C8) reduces diclofenac clearance.
What to do
Use the lowest effective diclofenac dose and monitor for NSAID adverse effects, particularly with oral formulations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Diclofenac with Mifepristone?
MediHelp rates the interaction as moderate. Diclofenac and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP2C9 and CYP2C8, which may increase systemic exposure to diclofenac. With topical diclofenac systemic exposure is low, so the effect is usually small, but oral use carries greater risk.
How serious is the interaction between Diclofenac and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective diclofenac dose and monitor for NSAID adverse effects, particularly with oral formulations.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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