Drug interactions
Diclofenac + Mirdametinib
Severity: Moderate
Diclofenac and Mirdametinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac inhibits UGT enzymes and may increase mirdametinib exposure. The effect has not been studied clinically.
What this interaction means in plain words
Diclofenac and Mirdametinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Mirdametinib belongs to Oncology.
Why it happens
Diclofenac may inhibit UGT-mediated metabolism of mirdametinib.
What to do
Monitor for mirdametinib toxicity, including skin reactions. Consider another analgesic if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirdametinib
- Mirdametinib + Probenecid Moderate
- Mirdametinib + Rifampicin Moderate
Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Mirdametinib?
MediHelp rates the interaction as moderate. Diclofenac and Mirdametinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diclofenac inhibits UGT enzymes and may increase mirdametinib exposure. The effect has not been studied clinically.
How serious is the interaction between Diclofenac and Mirdametinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mirdametinib toxicity, including skin reactions. Consider another analgesic if adverse effects emerge.
What other medicines interact with Mirdametinib?
MediHelp also lists interactions of Mirdametinib with, for example, Probenecid, Rifampicin. The full list is on the Mirdametinib page.
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