Drug interactions
Mirdametinib + Probenecid
Severity: Moderate
Mirdametinib and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid inhibits UGT enzymes and may increase mirdametinib exposure. No clinical studies have evaluated this, so the magnitude is unknown. Higher exposure could worsen MEK inhibitor toxicities such as rash or cardiomyopathy.
What this interaction means in plain words
Mirdametinib and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirdametinib belongs to Oncology; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits UGT-mediated glucuronidation of mirdametinib.
What to do
Monitor for mirdametinib adverse effects such as rash and decline in cardiac function. Consider an alternative to probenecid if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirdametinib
- Diclofenac + Mirdametinib Moderate
- Mirdametinib + Rifampicin Moderate
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Mirdametinib with Probenecid?
MediHelp rates the interaction as moderate. Mirdametinib and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid inhibits UGT enzymes and may increase mirdametinib exposure. No clinical studies have evaluated this, so the magnitude is unknown. Higher exposure could worsen MEK inhibitor toxicities such as rash or cardiomyopathy.
How serious is the interaction between Mirdametinib and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mirdametinib adverse effects such as rash and decline in cardiac function. Consider an alternative to probenecid if toxicity develops.
What other medicines interact with Mirdametinib?
MediHelp also lists interactions of Mirdametinib with, for example, Diclofenac, Rifampicin. The full list is on the Mirdametinib page.
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