Drug interactions
Mirdametinib + Rifampicin
Severity: Moderate
Mirdametinib and Rifampicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin may induce UGT enzymes and lower mirdametinib exposure, potentially reducing efficacy. This has not been studied clinically.
What this interaction means in plain words
Mirdametinib and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirdametinib belongs to Oncology; Rifampicin belongs to Anti Bacterial.
Why it happens
Rifampicin induces UGT-mediated glucuronidation of mirdametinib.
What to do
Where possible, use an alternative to rifampicin. If combined, monitor tumor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirdametinib
- Diclofenac + Mirdametinib Moderate
- Mirdametinib + Probenecid Moderate
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Mirdametinib with Rifampicin?
MediHelp rates the interaction as moderate. Mirdametinib and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampicin may induce UGT enzymes and lower mirdametinib exposure, potentially reducing efficacy. This has not been studied clinically.
How serious is the interaction between Mirdametinib and Rifampicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, use an alternative to rifampicin. If combined, monitor tumor response.
What other medicines interact with Mirdametinib?
MediHelp also lists interactions of Mirdametinib with, for example, Diclofenac, Probenecid. The full list is on the Mirdametinib page.
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