Drug interactions
Diclofenac + Nebivolol
Severity: Moderate
Diclofenac and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac may blunt the blood pressure lowering effect of nebivolol, particularly with regular use beyond about a week.
What this interaction means in plain words
Diclofenac and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Nebivolol belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandins and sodium and fluid retention oppose beta-blocker antihypertensive effect.
What to do
Monitor blood pressure during regular NSAID use and adjust antihypertensive therapy if needed. Use the lowest effective diclofenac dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Diclofenac with Nebivolol?
MediHelp rates the interaction as moderate. Diclofenac and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diclofenac may blunt the blood pressure lowering effect of nebivolol, particularly with regular use beyond about a week.
How serious is the interaction between Diclofenac and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during regular NSAID use and adjust antihypertensive therapy if needed. Use the lowest effective diclofenac dose for the shortest duration.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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