Drug interactions
Diclofenac + Nicardipine
Severity: Minor
Diclofenac and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may modestly increase diclofenac exposure by inhibiting its metabolism, which could heighten NSAID adverse effects. NSAIDs may also blunt the antihypertensive effect of nicardipine.
What this interaction means in plain words
Diclofenac and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diclofenac belongs to Musculoskeletal; Nicardipine belongs to Cardiovascular.
Why it happens
Possible CYP2C9 inhibition by nicardipine reduces diclofenac clearance, with NSAID sodium retention opposing antihypertensive action.
What to do
Use the lowest effective diclofenac dose and monitor blood pressure and for NSAID adverse effects such as GI or renal toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Diclofenac with Nicardipine?
MediHelp rates the interaction as minor. Diclofenac and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine may modestly increase diclofenac exposure by inhibiting its metabolism, which could heighten NSAID adverse effects. NSAIDs may also blunt the antihypertensive effect of nicardipine.
How serious is the interaction between Diclofenac and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective diclofenac dose and monitor blood pressure and for NSAID adverse effects such as GI or renal toxicity.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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