Drug interactions
Diclofenac + Oxaprozin
Severity: Major
Diclofenac and Oxaprozin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two systemic NSAIDs together does not improve efficacy and increases the risk of gastrointestinal bleeding, kidney injury and cardiovascular events. This duplication is generally avoidable.
What this interaction means in plain words
Diclofenac and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diclofenac belongs to Musculoskeletal; Oxaprozin belongs to Musculoskeletal.
Why it happens
Additive cyclooxygenase inhibition leads to duplicated gastrointestinal, renal, platelet and cardiovascular toxicity.
What to do
Avoid concurrent use and keep a single NSAID at the lowest effective dose. Add gastroprotection if NSAID therapy is needed in a high-risk patient.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Diclofenac with Oxaprozin?
MediHelp rates the interaction as major. Diclofenac and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using two systemic NSAIDs together does not improve efficacy and increases the risk of gastrointestinal bleeding, kidney injury and cardiovascular events. This duplication is generally avoidable.
How serious is the interaction between Diclofenac and Oxaprozin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and keep a single NSAID at the lowest effective dose. Add gastroprotection if NSAID therapy is needed in a high-risk patient.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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