Drug interactions
Diclofenac + Pexidartinib
Severity: Major
Diclofenac and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib carries a boxed warning for serious and potentially fatal liver injury. Diclofenac is also associated with hepatotoxicity, so combining them may raise the risk of liver injury.
What this interaction means in plain words
Diclofenac and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diclofenac belongs to Musculoskeletal; Pexidartinib belongs to Oncology.
Why it happens
Additive hepatotoxicity from two drugs that can independently injure the liver.
What to do
Avoid concomitant use where possible and choose a non-hepatotoxic analgesic such as paracetamol at limited doses. If unavoidable, monitor liver function tests closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Pexidartinib
Frequently asked questions
Can I take Diclofenac with Pexidartinib?
MediHelp rates the interaction as major. Diclofenac and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib carries a boxed warning for serious and potentially fatal liver injury. Diclofenac is also associated with hepatotoxicity, so combining them may raise the risk of liver injury.
How serious is the interaction between Diclofenac and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use where possible and choose a non-hepatotoxic analgesic such as paracetamol at limited doses. If unavoidable, monitor liver function tests closely.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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