Drug interactions
Diclofenac + Prasugrel
Severity: Major
Diclofenac and Prasugrel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac impairs platelet function and damages the gastric mucosa, while prasugrel is a potent antiplatelet agent. Together they raise the risk of clinically significant bleeding, especially gastrointestinal.
What this interaction means in plain words
Diclofenac and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diclofenac belongs to Musculoskeletal; Prasugrel belongs to Cardiovascular.
Why it happens
Additive platelet inhibition (COX inhibition plus P2Y12 blockade) with NSAID gastric mucosal injury.
What to do
Avoid regular NSAID use with prasugrel where possible; if unavoidable, use a gastroprotective proton pump inhibitor and monitor for bleeding and anemia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Prasugrel
Frequently asked questions
Can I take Diclofenac with Prasugrel?
MediHelp rates the interaction as major. Diclofenac and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diclofenac impairs platelet function and damages the gastric mucosa, while prasugrel is a potent antiplatelet agent. Together they raise the risk of clinically significant bleeding, especially gastrointestinal.
How serious is the interaction between Diclofenac and Prasugrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use with prasugrel where possible; if unavoidable, use a gastroprotective proton pump inhibitor and monitor for bleeding and anemia.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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