Drug interactions
Diclofenac + Probenecid
Severity: Moderate
Diclofenac and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid can raise diclofenac concentrations, increasing the likelihood of NSAID adverse effects such as gastrointestinal and renal toxicity. Diclofenac does not meaningfully impair probenecid's uricosuric action.
What this interaction means in plain words
Diclofenac and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits renal organic anion transport and glucuronidation, reducing diclofenac elimination.
What to do
Use the lowest effective diclofenac dose and monitor for GI, renal and cardiovascular adverse effects. Reduce the diclofenac dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Diclofenac with Probenecid?
MediHelp rates the interaction as moderate. Diclofenac and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid can raise diclofenac concentrations, increasing the likelihood of NSAID adverse effects such as gastrointestinal and renal toxicity. Diclofenac does not meaningfully impair probenecid's uricosuric action.
How serious is the interaction between Diclofenac and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective diclofenac dose and monitor for GI, renal and cardiovascular adverse effects. Reduce the diclofenac dose if adverse effects appear.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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