Drug interactions
Diclofenac + Rifapentine
Severity: Minor
Diclofenac and Rifapentine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces hepatic enzymes and may lower diclofenac concentrations. The effect is expected to be modest and mainly results in reduced efficacy.
What this interaction means in plain words
Diclofenac and Rifapentine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diclofenac belongs to Musculoskeletal; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induces CYP2C9 and related enzymes, increasing diclofenac metabolism.
What to do
Monitor analgesic response and adjust diclofenac within the approved dose range if the effect is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Diclofenac with Rifapentine?
MediHelp rates the interaction as minor. Diclofenac and Rifapentine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifapentine induces hepatic enzymes and may lower diclofenac concentrations. The effect is expected to be modest and mainly results in reduced efficacy.
How serious is the interaction between Diclofenac and Rifapentine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and adjust diclofenac within the approved dose range if the effect is inadequate.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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