Drug interactions
Diclofenac + Secobarbital
Severity: Minor
Diclofenac and Secobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and may speed up diclofenac clearance, which could reduce its analgesic or anti-inflammatory effect. The effect is expected to be modest and is mainly theoretical for a short-acting barbiturate.
What this interaction means in plain words
Diclofenac and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diclofenac belongs to Musculoskeletal; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate-mediated induction of hepatic metabolism, including CYP2C9, may increase diclofenac clearance.
What to do
No routine change is needed; if pain control is inadequate during repeated barbiturate use, reassess the diclofenac dose or choose another analgesic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Diclofenac with Secobarbital?
MediHelp rates the interaction as minor. Diclofenac and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce hepatic enzymes and may speed up diclofenac clearance, which could reduce its analgesic or anti-inflammatory effect. The effect is expected to be modest and is mainly theoretical for a short-acting barbiturate.
How serious is the interaction between Diclofenac and Secobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; if pain control is inadequate during repeated barbiturate use, reassess the diclofenac dose or choose another analgesic.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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