Drug interactions
Diclofenac + Sparsentan
Severity: Moderate
Diclofenac and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan, an endothelin and angiotensin receptor antagonist, reduces glomerular pressure, and NSAIDs can worsen kidney function in this setting. Sparsentan is also a weak CYP2C9 inducer, which may modestly reduce diclofenac exposure.
What this interaction means in plain words
Diclofenac and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Sparsentan belongs to Genitourinary.
Why it happens
NSAID inhibition of renal prostaglandins combined with RAAS and endothelin blockade, plus CYP2C9 induction by sparsentan.
What to do
Monitor serum creatinine, potassium and blood pressure when an NSAID is used, and limit NSAID duration. Check diclofenac efficacy and consider an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Diclofenac with Sparsentan?
MediHelp rates the interaction as moderate. Diclofenac and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan, an endothelin and angiotensin receptor antagonist, reduces glomerular pressure, and NSAIDs can worsen kidney function in this setting. Sparsentan is also a weak CYP2C9 inducer, which may modestly reduce diclofenac exposure.
How serious is the interaction between Diclofenac and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium and blood pressure when an NSAID is used, and limit NSAID duration. Check diclofenac efficacy and consider an alternative analgesic.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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