Drug interactions
Dicyclomine + Dimenhydrinate
Severity: Moderate
Dicyclomine and Dimenhydrinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate contains diphenhydramine, a potent antimuscarinic antihistamine. Combined with dicyclomine it can cause additive dry mouth, urinary retention, constipation, blurred vision, sedation and confusion, especially in older adults.
What this interaction means in plain words
Dicyclomine and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Dimenhydrinate belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic toxicity and avoid the combination in older adults or those with urinary retention or glaucoma. Choose a non-anticholinergic antiemetic if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dicyclomine with Dimenhydrinate?
MediHelp rates the interaction as moderate. Dicyclomine and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate contains diphenhydramine, a potent antimuscarinic antihistamine. Combined with dicyclomine it can cause additive dry mouth, urinary retention, constipation, blurred vision, sedation and confusion, especially in older adults.
How serious is the interaction between Dicyclomine and Dimenhydrinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and avoid the combination in older adults or those with urinary retention or glaucoma. Choose a non-anticholinergic antiemetic if possible.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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