Drug interactions
Dicyclomine + Diphenoxylate-atropine
Severity: Moderate
Dicyclomine and Diphenoxylate-atropine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both products have antimuscarinic activity, so combining them increases the risk of dry mouth, blurred vision, urinary retention, tachycardia and constipation. Reduced gut motility from both drugs may rarely progress to ileus or toxic megacolon in susceptible patients.
What this interaction means in plain words
Dicyclomine and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Diphenoxylate-atropine belongs to Gastrointestinal Tract.
Why it happens
Additive antimuscarinic effects from atropine and dicyclomine.
What to do
Monitor for anticholinergic adverse effects and abdominal distension, and avoid the combination in patients with urinary obstruction, glaucoma or ileus risk. Limit duration of therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Dicyclomine with Diphenoxylate-atropine?
MediHelp rates the interaction as moderate. Dicyclomine and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both products have antimuscarinic activity, so combining them increases the risk of dry mouth, blurred vision, urinary retention, tachycardia and constipation. Reduced gut motility from both drugs may rarely progress to ileus or toxic megacolon in susceptible patients.
How serious is the interaction between Dicyclomine and Diphenoxylate-atropine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and abdominal distension, and avoid the combination in patients with urinary obstruction, glaucoma or ileus risk. Limit duration of therapy.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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