Drug interactions
Dicyclomine + Dosulepin
Severity: Moderate
Dicyclomine and Dosulepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a tricyclic antidepressant with significant anticholinergic activity. Combined with dicyclomine it can cause excess anticholinergic effects including constipation, urinary retention, tachycardia, confusion and blurred vision.
What this interaction means in plain words
Dicyclomine and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Dosulepin belongs to Central Nervous System.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic toxicity, particularly in older patients, and reduce dose or switch to a less anticholinergic agent if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dicyclomine with Dosulepin?
MediHelp rates the interaction as moderate. Dicyclomine and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a tricyclic antidepressant with significant anticholinergic activity. Combined with dicyclomine it can cause excess anticholinergic effects including constipation, urinary retention, tachycardia, confusion and blurred vision.
How serious is the interaction between Dicyclomine and Dosulepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, particularly in older patients, and reduce dose or switch to a less anticholinergic agent if symptoms develop.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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