Drug interactions
Dicyclomine + Fesoterodine
Severity: Moderate
Dicyclomine and Fesoterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block muscarinic receptors, so taking them together adds to anticholinergic effects such as dry mouth, constipation, blurred vision, urinary retention and confusion. Older patients are at particular risk of these effects.
What this interaction means in plain words
Dicyclomine and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Fesoterodine belongs to Genitourinary.
Why it happens
Additive antimuscarinic pharmacodynamic effects at peripheral and central muscarinic receptors.
What to do
Avoid combining where possible, especially in older adults. If both are needed, monitor for urinary retention, constipation, cognitive changes and tachycardia, and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dicyclomine and Fesoterodine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Fesoterodine
Frequently asked questions
Can I take Dicyclomine with Fesoterodine?
MediHelp rates the interaction as moderate. Dicyclomine and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs block muscarinic receptors, so taking them together adds to anticholinergic effects such as dry mouth, constipation, blurred vision, urinary retention and confusion. Older patients are at particular risk of these effects.
How serious is the interaction between Dicyclomine and Fesoterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, especially in older adults. If both are needed, monitor for urinary retention, constipation, cognitive changes and tachycardia, and use the lowest effective doses.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
