Drug interactions
Dicyclomine + Galantamine
Severity: Moderate
Dicyclomine and Galantamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Galantamine raises acetylcholine levels while dicyclomine blocks its muscarinic action, so each may reduce the effect of the other. This can lessen the cognitive benefit of galantamine and the antispasmodic effect of dicyclomine.
What this interaction means in plain words
Dicyclomine and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Galantamine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between a cholinesterase inhibitor and a muscarinic antagonist.
What to do
Avoid the combination in dementia where possible. If dicyclomine is essential, monitor cognition and function and consider a non-anticholinergic alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Dicyclomine with Galantamine?
MediHelp rates the interaction as moderate. Dicyclomine and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Galantamine raises acetylcholine levels while dicyclomine blocks its muscarinic action, so each may reduce the effect of the other. This can lessen the cognitive benefit of galantamine and the antispasmodic effect of dicyclomine.
How serious is the interaction between Dicyclomine and Galantamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in dementia where possible. If dicyclomine is essential, monitor cognition and function and consider a non-anticholinergic alternative.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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