Drug interactions
Dicyclomine + Oxybutynin
Severity: Moderate
Dicyclomine and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are potent antimuscarinic agents, so use together substantially increases anticholinergic burden. This raises the risk of urinary retention, severe constipation, dry mouth, blurred vision, confusion and heat intolerance.
What this interaction means in plain words
Dicyclomine and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Oxybutynin belongs to Genitourinary.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Avoid duplicate anticholinergic therapy where possible, particularly in older adults. If both are needed, monitor for retention, constipation and cognitive effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Oxybutynin
Frequently asked questions
Can I take Dicyclomine with Oxybutynin?
MediHelp rates the interaction as moderate. Dicyclomine and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are potent antimuscarinic agents, so use together substantially increases anticholinergic burden. This raises the risk of urinary retention, severe constipation, dry mouth, blurred vision, confusion and heat intolerance.
How serious is the interaction between Dicyclomine and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate anticholinergic therapy where possible, particularly in older adults. If both are needed, monitor for retention, constipation and cognitive effects.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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