Drug interactions
Dicyclomine + Scopolamine
Severity: Moderate
Dicyclomine and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dicyclomine is an antimuscarinic antispasmodic, so adding scopolamine duplicates anticholinergic activity. This increases the risk of dry mouth, constipation, urinary retention, tachycardia, blurred vision and confusion.
What this interaction means in plain words
Dicyclomine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Scopolamine belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid concurrent use where possible. If both are needed, monitor for anticholinergic toxicity and reduce the dose of one agent as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dicyclomine and Scopolamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Scopolamine
Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Dicyclomine with Scopolamine?
MediHelp rates the interaction as moderate. Dicyclomine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dicyclomine is an antimuscarinic antispasmodic, so adding scopolamine duplicates anticholinergic activity. This increases the risk of dry mouth, constipation, urinary retention, tachycardia, blurred vision and confusion.
How serious is the interaction between Dicyclomine and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If both are needed, monitor for anticholinergic toxicity and reduce the dose of one agent as needed.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
