Drug interactions
Dicyclomine + Tolterodine
Severity: Moderate
Dicyclomine and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents block muscarinic receptors, so together they can produce stronger anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision and cognitive impairment. The burden is greater in older adults and those with glaucoma or obstructive conditions.
What this interaction means in plain words
Dicyclomine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Tolterodine belongs to Genitourinary.
Why it happens
Additive antagonism at muscarinic receptors.
What to do
Monitor for anticholinergic adverse effects and avoid concurrent use in patients with narrow-angle glaucoma, urinary retention or cognitive impairment. Consider an alternative to one agent if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Tolterodine
Frequently asked questions
Can I take Dicyclomine with Tolterodine?
MediHelp rates the interaction as moderate. Dicyclomine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents block muscarinic receptors, so together they can produce stronger anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision and cognitive impairment. The burden is greater in older adults and those with glaucoma or obstructive conditions.
How serious is the interaction between Dicyclomine and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and avoid concurrent use in patients with narrow-angle glaucoma, urinary retention or cognitive impairment. Consider an alternative to one agent if symptoms develop.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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