Drug interactions
Didanosine + Moxifloxacin
Severity: Moderate
Didanosine and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buffered didanosine formulations contain magnesium and aluminium antacids that bind moxifloxacin in the gut and reduce its absorption. This may lead to subtherapeutic antibiotic concentrations and treatment failure.
What this interaction means in plain words
Didanosine and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Didanosine belongs to Anti Virals; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Chelation of moxifloxacin by polyvalent cations in buffered didanosine, reducing oral absorption.
What to do
Give moxifloxacin at least 2 hours before or several hours after buffered didanosine. Delayed-release didanosine capsules lack this buffer and are less of a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Frequently asked questions
Can I take Didanosine with Moxifloxacin?
MediHelp rates the interaction as moderate. Didanosine and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buffered didanosine formulations contain magnesium and aluminium antacids that bind moxifloxacin in the gut and reduce its absorption. This may lead to subtherapeutic antibiotic concentrations and treatment failure.
How serious is the interaction between Didanosine and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give moxifloxacin at least 2 hours before or several hours after buffered didanosine. Delayed-release didanosine capsules lack this buffer and are less of a concern.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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