Drug interactions
Didanosine + Mycophenolate mofetil
Severity: Minor
Didanosine and Mycophenolate mofetil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buffered didanosine formulations raise gastric pH, which can reduce absorption of mycophenolate mofetil. Lower mycophenolic acid exposure could weaken immunosuppression.
What this interaction means in plain words
Didanosine and Mycophenolate mofetil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Didanosine belongs to Anti Virals; Mycophenolate mofetil belongs to Miscellaneous.
Why it happens
Increased gastric pH impairs dissolution and absorption of mycophenolate mofetil.
What to do
Give mycophenolate mofetil at least 2 hours before buffered didanosine formulations. Monitor for signs of rejection or reduced efficacy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Frequently asked questions
Can I take Didanosine with Mycophenolate mofetil?
MediHelp rates the interaction as minor. Didanosine and Mycophenolate mofetil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Buffered didanosine formulations raise gastric pH, which can reduce absorption of mycophenolate mofetil. Lower mycophenolic acid exposure could weaken immunosuppression.
How serious is the interaction between Didanosine and Mycophenolate mofetil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give mycophenolate mofetil at least 2 hours before buffered didanosine formulations. Monitor for signs of rejection or reduced efficacy.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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