Drug interactions
Didanosine + Nitrofurantoin
Severity: Minor
Didanosine and Nitrofurantoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buffered didanosine formulations contain antacids that raise gastric pH, and magnesium-containing antacids can reduce nitrofurantoin absorption. This may lower nitrofurantoin levels in urine, reducing efficacy, rather than increasing its effect.
What this interaction means in plain words
Didanosine and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Didanosine belongs to Anti Virals; Nitrofurantoin belongs to Anti Bacterial.
Why it happens
Buffering agents in didanosine formulations (magnesium/aluminium antacids) may impair nitrofurantoin absorption by adsorption and raised gastric pH.
What to do
Separate nitrofurantoin from buffered didanosine formulations by at least 2 hours. Monitor for clinical response to the antibiotic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nitrofurantoin
Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Frequently asked questions
Can I take Didanosine with Nitrofurantoin?
MediHelp rates the interaction as minor. Didanosine and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Buffered didanosine formulations contain antacids that raise gastric pH, and magnesium-containing antacids can reduce nitrofurantoin absorption. This may lower nitrofurantoin levels in urine, reducing efficacy, rather than increasing its effect.
How serious is the interaction between Didanosine and Nitrofurantoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate nitrofurantoin from buffered didanosine formulations by at least 2 hours. Monitor for clinical response to the antibiotic.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Pretomanid, Aluminum hydroxide. The full list is on the Nitrofurantoin page.
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