Drug interactions
Didanosine + Rilpivirine
Severity: Minor
Didanosine and Rilpivirine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilpivirine needs an acidic environment and a meal for adequate absorption, while didanosine must be taken fasting. Simultaneous administration may reduce rilpivirine absorption.
What this interaction means in plain words
Didanosine and Rilpivirine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Didanosine belongs to Anti Virals; Rilpivirine belongs to Anti Virals.
Why it happens
Conflicting food requirements; no clinically significant pharmacokinetic interaction occurs when properly separated.
What to do
Take didanosine at least 2 hours before or 4 hours after rilpivirine; rilpivirine is taken with a meal.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Didanosine with Rilpivirine?
MediHelp rates the interaction as minor. Didanosine and Rilpivirine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rilpivirine needs an acidic environment and a meal for adequate absorption, while didanosine must be taken fasting. Simultaneous administration may reduce rilpivirine absorption.
How serious is the interaction between Didanosine and Rilpivirine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take didanosine at least 2 hours before or 4 hours after rilpivirine; rilpivirine is taken with a meal.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Ribavirin. The full list is on the Didanosine page.
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