Drug interactions
Didanosine + Selinexor
Severity: Moderate
Didanosine and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and other neurological effects, and didanosine can cause peripheral neuropathy. Additive neurological toxicity is possible, although no specific interaction is well characterized.
What this interaction means in plain words
Didanosine and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Didanosine belongs to Anti Virals; Selinexor belongs to Oncology.
Why it happens
Possible additive neurotoxicity; no pharmacokinetic mechanism is established.
What to do
Monitor for dizziness, confusion and neuropathy and counsel on fall risk. Reduce or interrupt selinexor if neurological symptoms become significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Didanosine with Selinexor?
MediHelp rates the interaction as moderate. Didanosine and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and other neurological effects, and didanosine can cause peripheral neuropathy. Additive neurological toxicity is possible, although no specific interaction is well characterized.
How serious is the interaction between Didanosine and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and neuropathy and counsel on fall risk. Reduce or interrupt selinexor if neurological symptoms become significant.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Ribavirin. The full list is on the Didanosine page.
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