Drug interactions
Didanosine + Tipranavir
Severity: Moderate
Didanosine and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir capsules or solution co-ritonavir may be affected by the buffering and administration requirements of didanosine. Taking them together could reduce didanosine exposure, and the dosing conditions differ because tipranavir needs food.
What this interaction means in plain words
Didanosine and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Didanosine belongs to Anti Virals; Tipranavir belongs to Anti Virals.
Why it happens
Mechanism is not firmly established; altered gastric conditions and differing food requirements may reduce didanosine absorption.
What to do
Separate doses by at least 2 hours, with didanosine on an empty stomach. Monitor viral load.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Didanosine with Tipranavir?
MediHelp rates the interaction as moderate. Didanosine and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir capsules or solution co-ritonavir may be affected by the buffering and administration requirements of didanosine. Taking them together could reduce didanosine exposure, and the dosing conditions differ because tipranavir needs food.
How serious is the interaction between Didanosine and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by at least 2 hours, with didanosine on an empty stomach. Monitor viral load.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Ribavirin. The full list is on the Didanosine page.
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