Drug interactions
Dienogest / estradiol valerate + Fluconazole
Severity: Moderate
Dienogest / estradiol valerate and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may increase exposure to estradiol and dienogest by inhibiting CYP3A4. This may cause more nausea, breast tenderness, headache and irregular bleeding.
What this interaction means in plain words
Dienogest / estradiol valerate and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism of dienogest and estradiol by fluconazole.
What to do
Monitor for hormonal adverse effects and reassess if they become troublesome. Effects should resolve after fluconazole is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Dienogest / estradiol valerate with Fluconazole?
MediHelp rates the interaction as moderate. Dienogest / estradiol valerate and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole may increase exposure to estradiol and dienogest by inhibiting CYP3A4. This may cause more nausea, breast tenderness, headache and irregular bleeding.
How serious is the interaction between Dienogest / estradiol valerate and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hormonal adverse effects and reassess if they become troublesome. Effects should resolve after fluconazole is stopped.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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