Drug interactions
Dienogest / estradiol valerate + Insulin degludec-insulin aspart
Severity: Moderate
Dienogest / estradiol valerate and Insulin degludec-insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined estrogen-progestin products may impair glucose tolerance and slightly increase insulin requirements in diabetic patients. The effect is usually modest.
What this interaction means in plain words
Dienogest / estradiol valerate and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Estrogen and progestin effects on hepatic glucose output and insulin sensitivity oppose insulin action.
What to do
Monitor glucose when starting or stopping the hormonal product and adjust the insulin dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Frequently asked questions
Can I take Dienogest / estradiol valerate with Insulin degludec-insulin aspart?
MediHelp rates the interaction as moderate. Dienogest / estradiol valerate and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined estrogen-progestin products may impair glucose tolerance and slightly increase insulin requirements in diabetic patients. The effect is usually modest.
How serious is the interaction between Dienogest / estradiol valerate and Insulin degludec-insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting or stopping the hormonal product and adjust the insulin dose if control worsens.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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